Upregulation of Orai(l) Contributes To Excessive Cell Proliferation and Migration in Esophageal Squamous Carcinoma Cancer

摘要：

　　Objective:Store-operated Ca2+ entry (SOCE),an important Ca2+ signaling pathway,has been shown to involve into a diversity of cellular processes,including cell proliferation,apoptosis,tumor migration and metastasis.While Orail was recently identified as the long-sought channel pore-forming unit in SOCE pathway,the pathphysiological roles of Orail in various cancers have remained elusive.Here we majorly study the roles of Orail in the development and progression of esophageal squamous cell carcinoma (ESCC).

关键词： esophageal squamous cell carcinoma Orai(l) Store-operated Ca2+ entry (SOCE) cell proliferation metastasis

作者: Zhang Hui Fu Liwu

作者单位: State Key Laboratory of Oncology in Southern China,Cancer Center,Sun-Yat-Sen University,Guangzhou 510060,China

会议类型: 国内会议

会议名称: 2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会

会议地点: 深圳

会议语种:英文

页码: 423-424

在线出版日期: 2012-07-13（万方平台首次上网日期，不代表论文的发表时间）