Oleanolic Acid Suppresses Migration and Invasion of Malignant Glioma through Deactivating MAPK/ERK Signaling Pathway

摘要：

　　Mitogen-activated protein kinases/Extracellular signal-regulated kinase (MAPK/ERK) pathway is essential for migratory and invasive properties of malignant glioma.Targeting this pathway was shown to be efficient to inhibit migration and invasion of glioma cells.High dose of oleanolic acid (OA) has been widely demonstrated to suppress survival,growth and angiogenesis of glioma cells.In this study,we found that OA significantly decreased the ability of glioma cells to migrate and invade even at low dose where their survival and growth were not affected.Multiple pathwayscreening showed that activation of MAPK/ERK pathway was greatly inhibited under low concentration of OA treatment.Further immunoblotting assays confirmed that MAPK/ERK signaling was blocked by OA in glioma cells.

关键词： Oleanolic acid glioma EMT invasion migration

作者: Guocai Guo Weicheng Yao Jia Liu Yongli Bo

作者单位: Department of Neurosurgery,The Affiliated Hospital of Medical College,Qingdao University,Qingdao 266 Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China

会议类型: 国内会议

会议名称: 2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会

会议地点: 深圳

会议语种:英文

页码: 428-428

在线出版日期: 2012-07-13（万方平台首次上网日期，不代表论文的发表时间）