BIRB796,the Inhibitor of p38 Mitogen-Activated Protein Kinase,Enhances the Efficacy of Chemotherapeutic Agents in ABCB1 Overexpression Cells

摘要：

　　ATP-binding-cassette family membrane proteins play an important role in multidrug resistance.In this study,we investigated the possible interaction of BIRB796,an orally active inhibitor of p38 mitogen-activated protein kinase,with ABCB1,ABCG2 and ABCC1.Our results showed that BIRB796 could reverse ABCB1-mediated MDR to chemotherapeutic agents such as doxorubicin and paclitaxel in both the drug selected and transfected ABCB1-overexpressing cells,but had no enhancement effect on their parental sensitive cells and ABCC1 and ABCG2 overexpression cells.

作者: Dan He Guo-qing Zhang

作者单位: Department of Thoracic Surgery,Affiliated Tumor Hospital Xinjiang Medical University,Urumuqi 830011,China

会议类型: 国内会议

会议名称: 2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会

会议地点: 深圳

会议语种:英文

页码: 451-451

在线出版日期: 2012-07-13（万方平台首次上网日期，不代表论文的发表时间）