The genetic variants of Fas/FasL genes are associated with epithelial ovarian cancer susceptibility and outcome

摘要：

　　Aim:The Fas/FasL system has been suggested playing an important role in tumorigenesis and progression of cancer patient.In this study,we evaluated whether the functional polymorphisms on the FAS and FASL gene were associated with risk of developing epithelial ovarian cancer (EOC)and survival of patients with EOC.Methods:A case-control study was performed in 342 patients with EOC and 344 control women.The genotype of three promoter region polymorphisms (Fas-1377G/A,-670 A/G and FasL-844 T/C) were determined using ligase detection reaction-polymerase chain reaction (LDR-PCR).

关键词： Fas gene FasL gene polymorphisms ovarian cancer risk clinical outcome

作者: Li Yan Hao Ya-li Kang Shan Wang Na Zhou Rong-Miao

作者单位: Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China 0500 Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, C

会议类型: 国内会议

会议名称: 2012遗传学进步促进粮食安全与人口健康高峰论坛

会议地点: 郑州

会议语种:英文

页码: 60-60

在线出版日期: 2012-08-13（万方平台首次上网日期，不代表论文的发表时间）