Advances in bromodomain-containing Proteins in Mental Retardation

摘要：

　　Eukaryotic chromatin is well organized,both spatially and temporally,with complexes composed of genomic DNA,histone proteins,and non-histone proteins.The amino-terminus of histone tails can be modified through acetylation,which relaxes chromatin and provides space for transcription factors (TFs) to regulate gene transcription.One particular protein domain,the bromodomain,has been identified to specifically bind acetyl-lysine residues at the N-terminus of histone proteins in vivo and in vitro.A hydrophobic pocket formed by the ZA and BC loops of bromodomain-containing proteins (BCPs) is responsible for acetyl-lysine recognition and binding specificity.

作者: Junlin Li Guifang Zhao Xiaocai Gao

作者单位: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Institute of Population and Health, College of Life Science, Northwest University, Xi”an 710069, People”s Republic of China

会议类型: 国内会议

会议名称: 2012遗传学进步促进粮食安全与人口健康高峰论坛

会议地点: 郑州

会议语种:英文

页码: 95-96

在线出版日期: 2012-08-13（万方平台首次上网日期，不代表论文的发表时间）