Blocking Follistatin-like 1 attenuates pulmonary fibrosis in mice

摘要：

　　Idiopathic pulmonary fibrosis (IPF) is an incurable fibrosing disorder that progresses relentlessly to respiratory failure.Follistatin-like 1 (Fstl1) is a TGF-b1 induced secretory glycoprotein whose functions are largely unknown.Here we showed that Fstl1 was up-regulated in lung tissue and lung primary fibroblasts from IPF patients,as well as in bleomycin-induced lung fibrosis in mice.Fstl1+/-mice were resistant to bleomycin-induced lung injury and displayed an attenuated interstitial fibrotic phenotype.

作者: Y Dong L Li X Liu W Ning

作者单位: College of Life Sciences, Nankai University, Tianjin, China, 300071

会议类型: 国内会议

会议名称: 2012遗传学进步促进粮食安全与人口健康高峰论坛

会议地点: 郑州

会议语种:英文

页码: 97-97

在线出版日期: 2012-08-13（万方平台首次上网日期，不代表论文的发表时间）