Effects of the C-Terminal Truncation in NS1 Protein of the 2009 Pandemic H1N1 Influenza Virus on Host Gene Expression

摘要：

　　The 2009 pandemic H1N1 influenza virus encodes an NS1 protein with 11 amino acids (aa) truncation at the C-terminus.The C-terminal tail of influenza virus NS1 protein constitutes a nucleolar localization signal (NoLS) and is the binding domain of the cellular pre-mRNA processing protein,poly(A)-binding protein Ⅱ (PABⅡ).Here,our studies showed that the C-terminaltruncated NS1 of the 2009 pandemic virus was inefficient at blocking host gene expression,extension of the truncated NS1 to its full length increased the inhibition of host gene expression.

作者: Jiagang Tu Jing Guo Anding Zhang Wenting Zhang Zongzheng Zhao Hongbo Zhou Cheng Liu Huanchun Chen Meilin Jin

作者单位: Unit of Animal Infectious Diseases,National Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,People”s Republic of China

会议类型: 国内会议

会议名称: 第九届全国微生物学青年学者学术研讨会

会议地点: 武汉

会议语种:英文

页码: 6-6

在线出版日期: 2012-07-13（万方平台首次上网日期，不代表论文的发表时间）