A Multicenter,Randomized Controlled Clinical Study on Ceftriaxone/Sulbactam and Cefoperazone/Sulbactam Injection in the Treatment of Respiratory and Urinary Tract Infections caused by Resistant Bacteria

摘要：

　　Background Cettriaxone/sulbactam(4∶1)is a novel β-lactam/β-lactamase-inhibitor combination injection.A clinical study was designed to evaluate its efficacy and safety in the treatment of respiratory and urinary infections caused by ceftriaxone-resistant bacteria comparing with cefoperazone/sulbactam(2∶1)on cefoperazone-resistant bacteria.Methods A total of 285 patients with respiratory or urinary tract infections were enrolled into this multicenter,open-label,randomized controlled clinical study,and the bacteria isolated from whom were either ceftriaxone-resistant or cefoperzaone-resistant.Two hundred fifty three patients completed the trial and 263 were enrolled into the ITT analysis.

关键词： Resistant bacterial infection Ceftriaxone/sulbactam Randomized controlled clinical study

作者: Xiaojuan Xin Yunhua Liao Yijiang Huang Yunkui Zhu Chunsheng Xi Weili Zhang Ling Zhong Bei Jia Wenxiang Huang Chongzhi Li Changzheng Wang Lixin Zhou Xiuzhen Sun Baosong Gui Xinghuo Tang

作者单位: Key Laboratory of Infectious and Parasitic Diseases in Chongqing,Infectious DiseaseDepartment,First First Affiliated Hospital of Guangxi Medical University,Nanning,China Hainan General Hospital,Haikou,China Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA,Lanzhou China and Second Affiliated Hospital of Chongqing Medical University,Chongqing China Secondary Affiliated Hospital of the Third Military Medical University,Chongqing,China Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai China Second Affiliated Hospital,Medicial School ofXi” an Jiaotong University,Xi” an,China

会议类型: 国内会议

会议名称: 中国药理学会第十一届全国化疗药理学术研讨会

会议地点: 贵阳

会议语种:英文

页码: 301-301

在线出版日期: 2012-07-01（万方平台首次上网日期，不代表论文的发表时间）