Inhibitory effects of IL-10 on TGF-β1-induced fibrosis in human dermal fibroblasts
Scarring is a significant symptomatic clinical problem and is pathologically characterized by the excessive transformation of fibroblasts to myofibroblasts and deposition of extracellular matrix (ECM) components.IL-10 has been identified as a candidate scar-improvement therapy based on preclinical studies.However,the molecular mechanisms of IL-10 involved in scar formation have not been fully elucidated.In this study,cultured human dermal fibroblasts were treated with TGF-β1 and IL-10.The mRNA and protein expression levels of type Ⅰ collagen (Co11),type Ⅲ collagen (Co13),alpha smooth muscle actin (α-SMA) and matrix metalloproteinase-1 (MMP1) were assessed by quantitative real-time PCR and western blot.
antifibrosis IL-10 myofibroblast fibroblast-populated collagen lattice (FPCL) contracture
Jihong Shi Xiongxiang Zhu Chaowu Tang Dahai Hu Xiaolong Hu Xiaozhi Bai Weixia Cai Yingjun Su Jiaqi Liu Hao Guan Ke Tao
Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, 17 Changle West Road,Xi ”an, Shaanxi 710032, China
国内会议
广州
英文
31-32
2012-08-30（万方平台首次上网日期，不代表论文的发表时间）