Synthesis and biological evaluation of Matijing-Su derivatives as potential anti-hepatitis B virus agents
A series of Matijing-Su (MTS,N-(N-benzoyl-L-phenylalanyl)-O-acetylL-phenylalanol) derivatives were synthesized and evaluated for their abilities to inhibit the replication of hepatitis B virus (HBV) DNA in HepG22.2.15 cells.Compounds 5r (IC50:1.31 μM,SI:326.31),5f (IC50:6.64 μM,SI:61.72),5a (IC50:6.87 μM,SI:42.74),5d (IC50:8.24 μM,SI:58.68) and 5h (IC50:10.28 μM,SI:47.21) etc.exhibited significant inhibitory on the replication of HBV DNA in 2.2.15 cells,which were better than those of the positive control lamivudine (IC50:82.42 μM,SI:41.59).
MTS derivatives synthesis biological evaluation anti-hepatitis B virus activity
Jing-Ying Qiu Chang-Xiao Liu Zheng-Ming Huang Pei-Xue Cao Wei-Dong Pan Bi-Xue Xu Xiao-Jiang Hao Guang-Yi Liang
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Scie Tianjin Institute of Pharmaceutical Research, 308 Anshan Xi Dao, Nankai District, Tianjin 300193, Ch 302 Hospital of PLA, 100 Xisihuan Zhong Road, Fengtai Beijing 100039, China The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Scie
国内会议
海口
英文
41-41
2012-11-01（万方平台首次上网日期，不代表论文的发表时间）