Interaction of Alisols and Hemoglobin using spectroscopic and molecular modeling methods
Alisols are the main pharmaceutical components of Alisma,a well known herb in Traditional Chinese Medicine (TCM).This paper investigated the molecular interaction mechanism of Alisols and Hemoglobin (Hb) by using Fluorescence and Circular Dichroism spectra in combination with molecular modeling under the simulated physiological conditions.Molecular modeling results that were in agreement with the experimental results revealed that the binding of Alisol B 23-acetate and Hb was much more than that with Alisol A 24-acetate,indicating that the difference was related to the structure of the side chain of which the opened one leads to the strong binding while the folded to the weak so that the former may be the steering group of Alisols.The conclusion should be of great assistant for studying the clinical use of Alisma.
Alisol B 23-acetate Alisol A 24-acetate Fluorescence spectra Circular Dichroism spectra molecular modeling
Fei Xua Lin-qun Zhang Wei Gu Qi-nan Wu
Nanjing University of Chinese Medicine, Nanjing 210046, China School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210000, China;Center for
国内会议
海口
英文
122-122
2012-11-01（万方平台首次上网日期，不代表论文的发表时间）