Digitoflavone inhibits I κ B α kinase and enhances apoptosis induced by TNF α through downregulation of expression of nuclear factor κ B-regulated gene products in human pancreatic cancer cells

摘要：

　　Tumor necrosis factor-α (TNFα) activates both cell death and cell survival pathways,thereby rendering most cancer cells resistant to its cytotoxicity.We found that pretreatment with digitoflavone,a plant flavonoid,greatly sensitized TNFα-induced apoptotic cell death in several human pancreatic cancer cells.In search of the molecular basis of the sensitization effect of digitoflavone,digitoflavone was found to inhibit TNFα-induced activation of nuclear transcription factor-kappa B (NF-κB) which is the main survival factor in TNFα signaling.

关键词： Digitoflavone Apoptosis TNFα NF-κB JNK Pancreatic carcinoma

作者: Xueting Cai Wuguang Lu Yang Yang Jie Yang Juan Ye Zhenhua Gu Chunping Hu Peng Cao

作者单位: Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China

会议类型: 国内会议

会议名称: 中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

会议地点: 海口

会议语种:英文

页码: 129-129

在线出版日期: 2012-11-01（万方平台首次上网日期，不代表论文的发表时间）