Two New Natural Products from the Fruits of Alpinia oxyphylla with Inhibitory Effects on Nitric Oxide Production in Lipopolysaccaride-Activated RAW264.7 Macrophage Cells

摘要：

　　Chemical investigation of the fruits of Alpinia oxyphylla led to the isolation of two new natural products,9-hydroxy epinootkatol (1),(S)-2-pentanol-2-O-β-D-glucopyranoside (2),in addition to nine known compounds,pinocembrin (3),tectochrysin (4),izalpinin(5),nookatone (6),yakuchinone A (7),protocatechuic acid (8),β-sitosterol (9),daucosterol (10) and β-sitosterol palmitate (11).Their structures were elucidated on basis of physicochemical constants and NMR spectral data analysis.The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined.The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 μg/mL,respectively.

关键词： Zingerberaceae Alpinia oxyphylla sesquiterpenoids structure elucidation anti-inflammatory effects

作者: Li Yong hui Wang Yong Lai Wei yong Zhang Jun qing Li Hai long

作者单位: School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571199, P.R.China;Hainan Provincial Key Laboratory of R&D on Tropical Medicinal Plants, Haikou 571199,P.R.China;Haikou Municipal Key Laboratory of Li Nationality Medicines, Haikou 571199,P.R.China

会议类型: 国内会议

会议名称: 中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

会议地点: 海口

会议语种:英文

页码: 146-146

在线出版日期: 2012-11-01（万方平台首次上网日期，不代表论文的发表时间）