Coniferyl ferulate, isolated from Radix Angelicae sinensis, reverses multidrug resistance via strong inhibition of GST and down-regulation of P-glycoprotein

摘要：

　　P-glycoprotein (P-gp) and glutathione-S-transferase (GST) are key players in multidrug resistance (MDR).Inhibition of the expression of P-gp and/or GST has emerged as a promising therapeutic strategy for the reversal of MDR.Coniferyl ferulate (CF),isolated from Radix Angelicae sinensis (RAS),strongly inhibited human placental GST.Its 50% inhibition concentration (IC50) was 0.3 μM,which is greater than an known GST pl-1 inhibitor,ethacrynic acid (EA),using the established HTS model.

关键词： coniferyl ferulate Radix Angelicae sinensis (Umbelliferae) multidrug resistance glutathione-S-transferase

作者: Chang Chen Xinhua Lu Zhiyong Yah Shaojing Li

作者单位: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700,China New Drug Research and Development Centre of North China Pharmaceutical Group Corporation,Hebei, 0500 College of life science and engineering, Southwest Jiaotong University, Chengdu 610031, China

会议类型: 国内会议

会议名称: 中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

会议地点: 海口

会议语种:英文

页码: 417-418

在线出版日期: 2012-11-01（万方平台首次上网日期，不代表论文的发表时间）