突变型胰岛素原对ERS和UPR通路的影响

摘要：

　　Objective To explore the effects of the (pre)proinsulin mutants related to human diabetes on β-cell dysfunction,(pre)proinsulin mutants,C(A7)Y,G(B8)S,G(C28)R,R(SP6)H and V(A3)L were observed.Detected the dominant-negative inhibition of wild-type proinsulin trafficking by mutants and investigated the action of aberrant disulfide on dominant negative effect.ERS and URP induced by mutants were examined.The study on the molecular pathogenesis of mutant (pre)proinsulin induced β-cell failure would provide valuable theoretical and experimental basis for clinical therapy.

作者: 崔景秋 孙楠 李京艳 张红艳 王瑜 冯凭

作者单位: 天津医科大学总医院代谢病科,300070

会议类型: 国内会议

会议名称: 第四届世界中西医结合大会

会议地点: 天津

会议语种:中文

页码: 376-377

在线出版日期: 2012-10-20（万方平台首次上网日期，不代表论文的发表时间）