Adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes
Accumulating evidence suggests that microRNAs(miRNAs)play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis,insulin resistance and inflammation.MiR-143 is a well-characterized miRNA involved in adipogenesisand may be involved in regulating insulin resistance.Tumor necrosis factor-α(TNF-a),leptin,resistin and interleukin-6(IL-6),have already been identified as main regulators of obesity and insulin activity.Therefore,we want to study the effect of these inflammatory cytokines on the expression of miR-143.In this study,TNF-α,resistin and leptin were shown to downregulate miR-143 expression in human adipocytes,while IL-6had no effect on miR-143 expression.These results suggest that the expression of miR-143 is affected by a variety off actors that are related to insulin sensitivity.Therefore,miR-143 may be an important mediator in the development of obesity-related insulin resistance.
hsa-miR-143 adipocyte tumor necrosis factor-α interleukin-6 resistin,leptin
LINGLING ZHU XIRONG GUO CHUNMEI SHI CHENBO JI GUANGFENG XU LING CHEN LEI YANG ZIYI FU XIANWEI CUI YIBING LU
Department of Endocrinology,Second Affiliated Hospital,Nanjing Medical University,Nanjing,Jiangsu 21 Institute of Pediatrics,Nanjing Medical University,Nanjing,Jiangsu 210029;State key Laboratory of Re State key Laboratory of Reproductive Medicine,Department of Children Health Care,Nanjing Maternal an Institute of Pediatrics,Nanjing Medical University,Nanjing,Jiangsu 210029 Department of Endocrinology,Second Affiliated Hospital,Nanjing Medical University,Nanjing,Jiangsu 21
国内会议
无锡
英文
410-415
2012-11-01（万方平台首次上网日期，不代表论文的发表时间）