Antimicrobial properties of extracts from Salvia Przewalskii Maxim against Staphylococcus aureus in vitro and in vivo
Objective:To investigate the antimicrobial properties of extracts from Salvia Przewalskii Maxim(Dazhidansheng,DZDS) in vitro and in vivo.Methods:In vitro,the antimicrobial effects of extracts from Salvia Przewalskii Maxim including ethanol and aqueous extracts were determined using the serial 2-fold dilution and the colony formation methods.In vivo,a sepsis mouse model challenge by Staphylococcus aureus was established to assess the anti-infectious effects of the extracts from Salvia Przewalskii Maxim.Results:The ethanol extract from Salvia Przewalskii Maxim significantly suppressed the growth of Staphylococcus aureus ATCC29213 and its” clinical isolated strains in vitro.However,this antimicrobial effect was not observed in Escherichia Coli25922 and related clinical isolates.In vivo,the ethanol extract significantly reduced the mortality of sepsis mice challenge by Staphylococcus aureus ATCC29213 compared with that of the model mice.And,the protection efficiency reached about 42.9%.Conclusion:The ethanol extract from Salvia Przewalskii Maxim displayed a good antimicrobial property against Staphylococcus aureus property in vitro and in vivo,and it may be a potential agent for the treatment of sepsis caused by Staphylococcus aureus.
Salvia Przewalskii Maxim Staphylococcus aureus Minimum Inhibitory concentration Bacterialsepsis
Yao Liu Xuewen Qiu Jing Ouyang Fang Liu Bo Yang Yongqing Cai Xianfeng Wang
Department of Pharmacy, Southwest Hospital of the Third Military Medical University, Chongqing, China
国内会议
成都
英文
7-14
2012-10-26（万方平台首次上网日期，不代表论文的发表时间）