Determination of tolbutamide and its metabolite in human plasma by high performance liquid chromatography

摘要：

　　Tolbutamide,an oral sulfonylurea oral hypoglycemic drug used in the treatment of Tyre Ⅱ diabetes mellitus was selected as the representative probe substrate for cytochrome P450 2C9 in vitro and in vivo.To investigate the pharmacokinetics of tolbutamide and its metabolite 4-Hydroxytolbutamide,a sensitive and selective methord of high performance liquid chromatography for the determination of tolbutamide and its metabolite 4-Hvdroxvtolbutamide in human plasma was developed and validated.

作者: Zhe Wang Peipei Pan Jun Luo Guo xin Hu

作者单位: Wenzhou Medical College, Wen zhou, 325035, China

会议类型: 国内会议

会议名称: 第十三次全国临床药理学学术大会

会议地点: 成都

会议语种:英文

页码: 359-360

在线出版日期: 2012-10-26（万方平台首次上网日期，不代表论文的发表时间）