Cholic acid treatment in LDLR knockout mice induces hypercholesterolemia and atherosclerosis in an FXR-independent mechanism

摘要：

　　Bile acids play important roles in the metabolism of cholesterol and other fat-soluble nutrients by enhancing solubility and activating farnesoid X receptor (FXR).Moreover,excessive amounts of bile acids in the liver and circulation can cause hepatic and endothelial inflammation.To investigate the role of bile acids and FXR in atherosclerosis,LDLR-/-mice were fed a chow diet supplemented with cholic acid (CA) or lithocholic acid (LCA),for 12 weeks.

关键词： Cholic acid FXR hypercholesterolemia atherosclerosis

作者: Ruyi Xue Pu Qin Ling Dong Si Zhang XiZhong Shen

作者单位: ZhongShan Hospital,Fudan University,Shanghai 200032 Wyeth Research.Cardiovascular & Metabolic Disease Research,Collegeville,PA 19426

会议类型: 国内会议

会议名称: 第二十一次全国中西医结合肝病学术会议

会议地点: 昆明

会议语种:英文

页码: 195-196

在线出版日期: 2012-08-01（万方平台首次上网日期，不代表论文的发表时间）