The effect of Magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in Lipopolysaccharide-Induced Acute Lung Injury in Mice

摘要：

　　Magnolol,a hydroxylated biphenyl compound isolated from Magnolia officinalis has been reported to have anti-inflammatory properties.The purpose of this study was to evaluate the effect of magnolol on acute lung injury induced by lipopolysaccharide in mice.Male BALB/c mice were pretreated with dexamethasone or magnolol 1 h before intranasal instillation of LPS.7 h after LPS administration,the myeloperoxidase in lung tissues,lung wet/dry ratio and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined.

关键词： magnolol lipopolysaccharide acute lung injury nuclear factor-kappaB Toll-like receptor

作者: FU Yunhe ZHANG Naisheng YANG Zhengtao LIU Bo FENG Xiaoshen LI Fenyang LIANG Dejie LIU Zhicheng LI Depeng CAO Yongguo ZHANG Xichen

作者单位: Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 1

会议类型: 国内会议

会议名称: 中国畜牧兽医学会第三届中国兽医临床大会

会议地点: 兰州

会议语种:英文

页码: 335-335

在线出版日期: 2012-08-01（万方平台首次上网日期，不代表论文的发表时间）