Evaluation of novel fusion proteins derived from extracellular matrix binding domains of LigB as vaccine candidates against leptospirosis in a hamster model
Leptospira binds to host extracellular matrix (ECM) through surface exposed outer membrane proteins called adhesin in order to initiate infection.Of various adhesins present on the surface of the spirochete,Leptospira-immunoglobulin like proteins (Lig proteins) and LipL32 are most abundant,widely distributed among pathogenic serovars and well characterized.Various fragments of Lig proteins (Ligcon4,Ligcon4-7.5,LigBcen2)and C-terminus fragment of LipL32 all of that bind to host ECM were fused,expressed and purified in soluble form as fusion proteins.
Fusion protein Extracellular matrix Lig proteins Leptospira interrogans
Yongguo Cao Syed M.Faisal Weiwei Yan Yu-Chen Chang Sean P.McDonough Naisheng Zhang Bruce L.Akey Yung-Fu Chang
Department of Population medicine and Diagnostic Sciences;College of Animal Science and Veterinary M Department of Population medicine and Diagnostic Sciences Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14 College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130095, China
国内会议
兰州
英文
571-571
2012-08-01（万方平台首次上网日期，不代表论文的发表时间）