G-protein coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors

摘要：

　　17-β-Estradiol (E2) is a steroid hormone involved in neuroprotection against excitotoxicity and other forms of brain injury.Through genomic and non-genomic mechanisms,E2 modulates neuronal excitability and signal transmission by regulating N-methyl-D-aspartate (NMDA)and non-NMDA receptors.However,the mechanisms and identity of the receptors involved remain unclear,even though studies have suggested that estrogen G-protein-coupled receptor 30(GPR30)is linked to protection against ischemic injury.In the culture cortical neurons,treatment with E2 and the GPR30 agonist G1 for 45 min attenuated the excitotoxicity induced by NMDA exposure.

关键词： estrogen GPR30 NMDA receptors DAPK1 neuron

作者: Ming-gao Zhao

作者单位: Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi”an 710032, China

会议类型: 国内会议

会议名称: 全国第三次麻醉药理学术会议

会议地点: 西安

会议语种:英文

页码: 127-128

在线出版日期: 2012-07-06（万方平台首次上网日期，不代表论文的发表时间）