CD20+ T-cell lymphoma clinicopathologic analysis of 2 cases and a review of the literature
Rare cases of CD20+ T-cell lymphoma have been reported,but the clinicopathologic spectrum of this disorder is not known.We report on two cases of CD20+ T cell lymphoma,one presented with predominantly nodal disease and diagnosed with angioimmunoblastic T-cell lymphoma,the other presented with extranodal disease involving nasal cavity and diagnosed with peripheral T cell lymphoma,unspecified.CD20 was uniformly and dimly expressed in the 2 cases,and the results of flow cytometric analysis of bown marrow and lymph node were consistent with the histological findings.Beyond that,interestingly,we have found a normal CD20dim/+ T-cell subset in peripheral blood or bown marrow of some other people and have thought that the results confirmed hypothesis on malignant transformation of a subpopular of T cells when CD20 expression is present in T-cell lymphoma.Meanwhile through a search of the English language literature,we reviewed reported cases of CD20-positive T cell malignancies including the present cases.Further cases must be evaluated to understand the clinical significance of the CD20 expression on the surface of T cell malignancies,because recognition of this is important for ensuring a correct diagnosis so that patients can be offered the most appropriate therapy.
CD20 T-cell lymphoma flow cytometric analysis histological findings
Yan-li Li Zhi-min Zhai
Department of Hematology, the Second Affiliated Hospital of Anhui Medical university, 678 Fu Rong Ro Department of Hematology, the Second Affiliated Hospital of Anhui Medical university, 678 Fu Rong Ro
国内会议
合肥
英文
152-152
2012-08-24（万方平台首次上网日期，不代表论文的发表时间）