TNF/TNFR1 signaling pathway and endocytoplasmic reticulum stress(ERs) mediated apoptosis are involved in ofloxacin and marbofloxacin-induced apoptosis of juvenile dog joint chondrocytes in early stage in vitro
Quinolones(QNs) are widely used for their broad antibacterial spectrum and good antibacterial activities,desirable pharmacokinetic characteristics and few cross reactions with other therapeutic agents.However,QNs have adverse effects including chondrotoxicity in juvenile animals,so the use of QNs is contraindicated in children and adolescents.In regarding to the chondrotoxicity of QNs,numerous studies have been done.The current hypothesis suggests that QNs compete with the β1 integrin receptors residing on chondrocyte surface for extracellular Mg ions,which leads to alternation in β1 integrin expression,or function and eventually results in chondrocyte death.Stupack et al(2001) demonstrated that caspase-8 could be recruited to unligated integrins in adherent cells and further initiate apoptosis in a death receptor-independent manner.Sheng et al(2008) found that ofloxacin induced rabbit”s chondrocyte apoptosis by causing disturbance of β1 integrin functions and subsequently through caspase-8-dependent mitochondrial pathway.
ofloxacin marbofloxacin TNF/TNFR1 ERs apoptosis
Fu-Tao Zhang Dan Xing Ming-Xing Ding
College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,430070,China
国内会议
第二届亚洲兽医外科学大会暨第19次中国畜牧兽医学会兽医外科学分会学术研讨会
南京
英文
46-47
2012-11-01（万方平台首次上网日期，不代表论文的发表时间）