Immunolocalization of β-catenin and Lef-1 during postnatal hair follicle development in mice
It is well recognized that the Wnt pathway,in which β-catenin and Lef-1 are important factors,is associated with many physiological processes,including embryogenesis and postnatal development.The Wnt pathway also plays a critical role in the development of skin.It regulates the formation of the dorsal dermis and epidermal appendages in the skin and the activity of epithelial stem cells.In this study,we investigated the presence and localization of β-catenin and Lef-1 in murine hair follicles through the first postnatal month,which encompasses the first hair cycle in mice,using Western blotting and immunohistochemistry.Our results show that β-catenin and Lef-1 are expressed during all stages in a hair cycle,most strongly in the anagen and weakly in the catagen and telogen phases.The results also suggest that the β-catenin-Lef-1 complex may regulate hair follicle cycling.This process will be of considerable interest to future studies.
β-catenin Lef-1 Hair follicle Hair follicle cycle Mice
Hai-Dong Wang Lei Yang Xiu-Ju Yu Jun-Ping He Lin-Hua Fan Yan-Jun Dong
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University Laboratory Animal Centre, Shanxi Medical University, Taiyuan, China College of Animal Science and
国内会议
中国畜牧兽医学会动物解剖学及组织胚胎学分会第十七次学术研讨会
山西太谷
英文
92-101
2012-07-01（万方平台首次上网日期，不代表论文的发表时间）