抑制性和激活性NK细胞KIR受体与HLA配体之间的相互作用对非清髓性外周血造血干细胞移植高风险患者移植预后的影响

摘要：

　　NK cell cytotoxicity is modulated by interaction between killer Ig-like receptors (KIR) and their ligands which may influence the outcomes of transplant through various mechanisms including graft versus leukemia (GVL) effect.The impact of the KIR alloreactions on leukemia relapse in myeloablative transplantation has been reported.In this study we examined the GVL effect in non-myeloablative transplantation in 46 myeloid malignancy (MM) and 34 lymphoid malignancy (LM) patients receiving peripheral blood hematopoietic stem cell graft from haploidentical family donors.Transplant outcomes were evaluated by using missing ligand,ligand-ligand model and by presence of activating KIR (aKIR).

关键词： 白血病 干细胞移植 临床治疗 NK细胞 KIR受体 HLA配体 预后分析

作者: Dong-Feng Chen Vinod K Prasad Gloria Broadwater Adella Clark David A Rizzieri Nelson J Chao Nancy L Reinsmoen

作者单位: Clinical Transplantation Immunology Laboratory Pediatric Blood and Marrow Transplantation Program Cancer Center Biostatistics Division of Cellular Therapy, Duke University Medical Center,Durham, NC, USA HLA Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health Systems, Los Angeles, CA, USA

会议类型: 国内会议

会议名称: 中华骨髓库第二届年会

会议地点: 北京

会议语种:中文

页码: 147-148

在线出版日期: 2009-05-01（万方平台首次上网日期，不代表论文的发表时间）