Detecting Rare variants in a Case-Control Association Study

摘要：

There is emerging interest in association studies of rare variants.But analyzing the group effect of multiple rare variants is challenging.Most association tests suggested in the literature involve collapsing sequence data with or without weighting strategy.These tests often have good power performance when there are many functional rare variants included in the study.However,the power of these tests may be dramatically reduced when there are many nonfunctional rare variants included.We propose a procedure that uses a model for describing the heterogeneous effects of rare variants.

作者: Cheng KF Lee JY

作者单位: Biostatistics Center,China Medical University,Taichung,Taiwan Graduate Institute of Statistics,National Central University,Chungli,Taiwan

会议类型: 国内会议

会议名称: 第四届临床评价方法与应用国际研讨会(2011)

会议地点: 北京

会议语种:英文

页码: 1-1

在线出版日期: 2011-07-02（万方平台首次上网日期，不代表论文的发表时间）