用3.0TMRI呈现3-硝基丙酸处理的豚鼠和急性听力损失患者血-内耳屏障转运增加
Objective To visualize the permeability changes in the blood-inner ear barriers of guinea pigs with acute mitochondria dysfunction and in patients with acute hearing loss using contrast agent-enhanced MRI.Materials and methods An animal model of acute mitochondria dysfunction-induced hearing loss was created by introducing 3-nitropropionic acid (3-NP) intratympanically in guinea pigs.Vestibular disorder and hearing loss were evaluated.An MRI was performed at 2 h after either intravenous (Ⅳ) or intratympanic administration of dimeglumine gadopentetate (Gd-DTPA),using 3D fast-recovery fast spin-echo (FRFSE) and 3D fluid-attenuated inversion recovery (FLAIR) sequences.
3-硝基丙酸 急性听力损失 血-内耳屏障转运
邹静
第二军医大学附属长海医院,上海,200433
国内会议
浙江舟山
中文
195-196
2011-06-26（万方平台首次上网日期，不代表论文的发表时间）