Complete Freund”s adjuvant treatment suppresses IL-17 production in a population of myeloid cells in nonobese diabetic mice
Some reports recently have shown that Th17 cells,as a distinct lineage from Th1 and Th2 subsets,play an obligatory role in autoimmune diabetes.It is well known that immunotherapy with Complete Freund”s adjuvant(CFA) is effective in preventing from the onset of diabetes in nonobese diabetic(NOD) mice.In the present study,we investigated whether CFA treatment restrains Th17 development and down-regulates Th17-related cytokine production in NOD mice.Thl7-related cytokine (i.e.IL-17A,IL-17F,IL-21,IL-22,IL-23,IL-6,TGF-β) production in splenocytes was decreased dramatically on day 18 following CFA immunization.
Xiaogang Gao Guoshan Ding Zhengxin Wang Hong Fu Zhijia Ni Jun Ma Fang Liu Zhiren Fu
Division of Liver Transplantation,Department of Organ Transplantation,Changzheng Hospital,the Second Military Medical University,Shanghai,P.R.China,200003
国内会议
成都
英文
181-181
2011-06-17（万方平台首次上网日期，不代表论文的发表时间）