Complement C3 deficiency prevent against the onset of streptozotocin-induced autoimmune diabetes involving expansion of regulatory T cells

摘要：

Recent studies have demonstrated that complement contributes to the development of autoimmune diabetes.However,the mechanisms remain unknown.Herein,using a model of streptozotocin (STZ)-induced diabetes,we found the presence of immune tolerance to self islet in complement C3-deficient mice after STZ.Higher number of CD4+CD25+ regulatory T cells(Tregs) with characteristics of expressing Foxp3was observed in C3-/-mice.These C3-/-Tregs exhibited enhanced suppressive capacity to effector cell proliferation.

作者: Xiaogang Gao Huanhai Liu Guoshan Ding Zhengxin Wang Hong Fu Zhijia Ni Jun Ma Fang Liu Zhiren Fu

作者单位: Division of Liver Transplantation,Department of Organ Transplantation,Changzheng Hospital,the Second Military Medical University,Shanghai,P.R.China,200003

会议类型: 国内会议

会议名称: 第五届全军器官移植学术会议

会议地点: 成都

会议语种:英文

页码: 182-182

在线出版日期: 2011-06-17（万方平台首次上网日期，不代表论文的发表时间）