Two New Nonacosanetriols from Ginkgo biloba Sarcotesta
Two new fatty alcohols named as(7S,8R，11S)-nonacosanetriol(1)and(10R，12R，15S)-nonacosanetriol(2)，along with eight known compounds including ginkgolic acid(3)，hydroginkgolic acid(4)，sciadopitysin(5)，ginkgetin(6)，isoginkgetin(7)，ginkgolide A(8)，ginkgolide B(9)and ginkgolide C(10)have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta．Their structures were elucidated by means ofchemical and extensive spectroscopic analysis．The absolute stereochemistry of compounds 1 and 2 were elucidated on the spectroscopic analysis of the R-and S-MTPA esters．Compounds 1 and 2 exhibited slight a ctivity of a ntithrombin and moderate activity of antiplatelet aggregation in vitro．It was also the first report a bout the anticoagulative a ctivities of biflavonoids in G．biloba，and isoginkgetin(7)showed significant antithrombin and antiplatelet aggregation activity．
Guisheng Zhou Yuping Tang Xin Yao Nianyun Yang Dawei Qian Shulan Su Chun Jin Yong Qin Jin-ao Duan
Jiangsu Key Laboratoryfor High Technology of TCM formulae Research，Nanjing University of Chinese Med Jiangsu Shenlong Pharmaceutical Co．，Ltd．，Yancheng 224200,China
国内会议
兰州
英文
391-392
2012-08-14（万方平台首次上网日期，不代表论文的发表时间）