3-Acetyl-11-keto-β-boswellic acid(AKBA)attenuates hepatic granuloma in C57BL/6 mice with Schistosoma japonicum infection
The egg antigens induce granuloma formation，and then granuloma can develop to fibrosis mainly in intestine and liver portal system．The hepatic fibrosis is the important cause of morbidity and mortality in human beings infected with schistosoma．The AKBA have been confirmed to have anti-inflammatory and immunomodulatory activity，however，much less is known regarding the role of AKBA in schistosome egg-induced liver granuloma．In this study，we investigated the effect of ABKA on Schistosoma japonicum(S．japonicum)egg-induced liver granuloma．The infected mice with S．japonicum cercariae were injected with AkBA at the onset of egg granuloma formation．Our results showed that AkBA treatment significantly reduced liver granuloma size in the liver．The protective effect of AkBA on liver granuloma was accompanied by increased LTB4 and PGE2 protein expression，and decreased MMP-9 mRNA and protein expression．Therefore，it is indicated that AKBA can significantly attenuate S．japonicum egg-induced hepatic ganuloma．which may be partly dependent on the increased some biochemical media．
Miao Liu Shengjian Dong Peng Cheng Dake Huang Cuiping Ren Yuxia Zhang Xin Hou Jijia Shen
Department of Parasitology,Anhui Medical University,Hefei,Anhui．230032，People’s Republic of China Department of Parasitology，Anhui Medical University，No．81，Meishan Road，Hefei，Anhui，230032，People’S R
国内会议
2012年安徽省医学会微生物与免疫学、热带病与寄生虫病学会换届改选与学术研讨会
黄山
英文
108-108
2012-08-11（万方平台首次上网日期，不代表论文的发表时间）