A phase I study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer
Purpose: Concurrent chemoradiotherapy with 5-fluorouracil and cisplatin are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. S-l, an oral 5-fluorouracil derivative, is effective against esophageal cancer with mild toxicity and synergistic effects with radiation. This phase I trail was designed to determine the maximum tolerated dose and dose-limiting toxcity of S-l when given with thoracic radiotherapy in elderly patients.Methods: Patients who were histologically confirmed to have oesophageal cancer, were age 70 years or older, and had an Eastern Cooperative Oncology Group (ECOG) score of 0-2 were eligible for this study. Thoracic radiation therapy was administered in 1.8 Gy fractions 5 times weekly to a total dose of 54 Gy. S-1 was administered on days 1-14 and 29-42 at the following dosages: 60, 70, and 80 mg/m2/day.Results: Between February 2010 and August 2011, 12 previously untreated patients were enrolled in this study. No grade 3 or 4 toxicity was observed in 6 patients treated at the 60 and 70 mg/m2 dose levels. Dose-limiting toxicity was observed in 4 of 6 patients treated at the 80 mg/m2 dose level. Two patients developed grade 3 oesophagitis, 1 patient developed grade 3 oe-sophagitis and grade 3 pneumonitis, and 1 patient developed grade 3 thrombocytopaenia. Complete response (CR) and partial response (PR) was observed in 8 patients (66.7％) and 3 patients (25%), respectively.Conclusion: The recommended dose of S-l is 70mg/m2/day, and this is a feasible and well-tolerated regimen for the treatment of elderly patients with oesophageal cancer.
Radiation S-1 Esophageal cancer Elderly
Yongling JI Xianghui DU Weimin MAO Guoqing QIU Shengye WANG Yaping XU Xiaojiang SUN Yuanda ZHENG
Department of Radiation and OncologyKey laboratory Diagnosis and Treatment Technology” on Thoracic Oncology, Zhejiang Province, China, Zhejiang Cancer Hospital,Hangzhou, China,310022
国内会议
杭州
英文
120
2012-06-29（万方平台首次上网日期，不代表论文的发表时间）