Water-Soluble and Biocompatible MnO@PVP Nanoparticles for MR Imaging In Vitro and In Vivo
(0) The uniform-sized MnO nanoparticles (the oleic-capped MnO NPs) weresynthesized by the thermal decomposition of Mn-oleate complex and were transferredinto water with the help of cationic surfactant of CTAB, then the PVP membrane wasfurther coated on to them with the aid of anionic dispersant of PSS by layer-by-layerelectrostatic assembly to render them water solubility and biocompatibility. They werecharacterized by transmission electron microscopy (TEM), dynamic light scattering(DLS), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) and MTT assay.In vitro cellular uptake test revealed the MnO@PVP NPs were low cytotoxic,biocompatible and could be used as a T1-positive contrast agent for passive targeting MR imaging. Interestingly, signal enhancement in cerebral spinal fluid (CSF) spacesin vivo experiment gave us great promising in detecting the breakage of theblood-brain barrier if the surfaces of the MnO@PVP NPs to be further modified withPEG or conjugated with active targeting probes. These results show that MnO@PVPNPs are good candidates for MRI contrast agents with the lack of cytotoxicity andhave great potential applications in magnetic nano-device and biomagnetic field.
Xiao-qing Hu Yu-xuan Ji Ming-liang Wang Fei Miao Hong-mei Ma He-bai Shen Neng-qin Jia
The Education Ministry Key Laboratory of Resource Chemistry,Department of Chemistry,Life and Environ Department of Radiology,Ruijin Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200
国内会议
2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
上海
英文
1-24
2012-08-15（万方平台首次上网日期，不代表论文的发表时间）