Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

摘要：

Graphene with unique physical and chemical properties has shown various potentialapplications in biomedicine. In this work, a photosensitizer molecule, Chlorin e6 (Ce6), is loaded onpolyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π
π stacking.The obtained GO-PEG-Ce6 complex shows excellent water solubility and is able to generate cytotoxicsinglet oxygen under light excitation for photodynamic therapy (PDT). Owing to the significantlyenhanced intracellular trafficking of photosensitizers, our GO-PEG-Ce6 complex offers a remarkablyimproved cancer cell photodynamic destruction effect compared to free Ce6. More importantly, weshow that the photothermal effect of graphene can be utilized to promote the delivery of Ce6molecules by mild local heating when exposed to a near-infrared laser at a low power density,further enhancing the PDT efficacy against cancer cells. Our work highlights the promise of usinggraphene for potential multifunctional cancer therapies.

关键词： graphene . Chlorin e6 . Photodynamic therapy . Photothermal effect .Combined therapies

作者: Bo Tian Chao Wang Shuai Zhang Liangzhu Feng Zhuang Liu

作者单位: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices,Institute of Functional Nano & Soft Materials (FUNSOM),Soochow University,Suzhou,Jiangsu,215123,People”s Republic of China

会议类型: 国内会议

会议名称: 2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛

会议地点: 上海

会议语种:英文

页码: 1-10

在线出版日期: 2012-08-15（万方平台首次上网日期，不代表论文的发表时间）