Fabrication of laponite doped poly(lactic-co-glycolic acid) nanofibers for drug encapsulation and sustained release
We report an efficient approach for fabricating organic/inorganic hybrid nanofibers for drugencapsulation and sustained release. In this study, a clay material, laponite (LAP), was first used toencapsulate amoxicillin (AMX) though ion exchange. The drug loaded LAP/AMX nanohybrid wassystematically characterized via different techniques. We show that LAP and AMX can be hybridized withan optimized loading percentage of about 10 ％ (w/w). Then, the LAP/AMX nanohybrid was incorporatedinto poly(lactic-co-glycolic acid) (PLGA) nanofibers though electrospinning to form a PLGA/LAP/AMXnanofibers based double-container drug delivery system (DDS). The fiber morphology was characterizedusing scanning electron microscopy (SEM). In vitro drug release behavior was examined using UV-Visspectroscopy. Finally, the antimicrobial activity of the PLGA/LAP/AMX nanofibers was investigatedagainst Staphylococcus aureus (S. Aureus) on solid medium. We show that the incorporation of LAP/AMXnanohybird did not significantly change the morphology of the PLGA nanofibers. The in vitro drug releasedata indicate that the PLGA/LAP/AMX nanofibers can avoid the burst release of AMX. Furtherantimicrobial activity and biocompatibility assays indicate that PLGA/LAP/AMX nanofibers shows nocompromise in antimicrobial activity relative to AMX powder and biocompatibility relative to PLGAnanofibers. We anticipate that this double-container DDS may find various applications in tissueengineering and pharmaceutical science.
Poly(lactic-co-glycolic acid) laponite electrospinning amoxicillin, encapsulation,sustained release, antimicrobial activity
Wang Shige Zheng Fuyin Shi Xiangyang
College of Materials Science and Engineering,Donghua University,Shanghai 201620 College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620
国内会议
2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
上海
英文
1-11
2012-08-15（万方平台首次上网日期，不代表论文的发表时间）