Dendrimer Tailored Highly Efficient Catalase Mimics of Pt Nanoparticles
In the present study, poly(amidoamine) (PAMAM) encapsulated platinumnanoparticles (Pt NPs) were synthesized and used to catalase mimics. Acetylatedgeneration 9 (G9) PAMAM dendrimer (Ac-G9) with a molecular size around 10 nmwere used as the Pt NPs synthesis template. The feeding molar ratio of Pt4+ andAc-G9 is 2048 and the synthesized platinum nanoparticles have an average size of 3.3nm. Ac-G9/Pt2048 has a similar molecular size (~11 nm) and globular shape withcatalase. The catalytic activity of Ac-G9/Pt2048 on the decomposition of H2O2 isapproaching that of catalase at 37 °C. Interestingly, Ac-G9/Pt2048 showed differentialresponse to the changes of pH and temperature. It may be explained by differentcatalytic mechanisms of Ac-G9/Pt2048 and catalase. Furthermore, Ac-G9/Pt2048 showsexcellent biocompatibility on different cell lines. It can down-regulate theH2O2-induced intracellular reactive oxygen species (ROS) in these cells. These resultssuggest that dendrimers are promising mimics of proteins with different sizes andAc-G9/Pt2048 can be used as an alternative candidate of catalase to decrease theoxidation stress in cells.
dendrimer, platinum nanoparticle, catalase mimic
Nanoparticles Yincong Zhang Xintao Qian Qiang Zhang Yiyun Cheng
School of Life sciences,East China Normal University,Shanghai,200062,People”s Republic of China
国内会议
2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
上海
英文
1-18
2012-08-15（万方平台首次上网日期，不代表论文的发表时间）