A NaYbF4: Tm3t nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging

摘要：

Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging couldprovide more accurate information for cancerous tissues, which, however, remain a big challenge. Herewe report a simple bimodal imaging platform based on PEGylated NaYbF4: Tm3t nanopaticles (NPs) ofless than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobesshowed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and nodetectable tissue damge in one month. Remarkably, the Yb3t in the lattice of NaYbF4: Tm3t NPs functionsnot only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also anexcellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorptioncross-section. In addition, these NPs could be easily excreted mainly via feces without detectableremnant in the animal bodies.

关键词： CT NIR-fluorescence Contrast medium Small animal imaging

作者: Huaiyong Xing Kuaile Zhao Liangping Zhou Weijun Peng Jianlin Shi Wenbo Bu Qingguo Ren Xiangpeng Zheng Ming Li Shengjian Zhang Haiyun Qu Zheng Wang Yanqing Hua

作者单位: State Key Laboratory of High Performance Ceramics and Superfine Microstructures,Shanghai Institute o Department of Radiology,Shanghai Cancer Hospital,Fudan University,Shanghai 200032,PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructures,Shanghai Institute o Department of Radiation Oncology,Shanghai Huadong Hospital,Fudan University,Shanghai 200040,PR China

会议类型: 国内会议

会议名称: 2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛

会议地点: 上海

会议语种:英文

页码: 1-10

在线出版日期: 2012-08-15（万方平台首次上网日期，不代表论文的发表时间）