Calcium Phosphate Nano-Carriers Dual-Loaded with Bovine Serum Albumin and Ibuprofen: Facile Synthesis, Sequential Drug Loading and Sustained Drug Release
We report a simple andgreen strategy for the preparation anddrug loading and release properties ofthe drug delivery system consisting ofcalcium phosphate (CP) nano-carriersand dual-loaded bovine serum albumin(BSA) and hydrophobic drug ibuprofen(IBU). The sequential loading of BSAand IBU in calcium phosphate nanocarriersand in vitro simultaneousrelease of BSA and IBU are realizedand investigated. In this method, BSA, is in-situ encapsulated in calciumphosphate nano-carriers, andsubsequently a typical hydrophobicdrug IBU is loaded in the BSA/CP drugdelivery system, forming theIBU/BSA/CP dual-drug deliverysystem. The experiments reveal that the preloaded BSA not only reduces thecytotoxicity of calcium phosphatenano-carriers but also significantlyimproves the IBU drug loadingcapacity in calcium phosphate nanocarriersand greatly extends theduration of drug release. Thus, the aspreparedIBU/BSA/CP dual-drugdelivery system is promising for drugdelivery applications.
bovine serum albumin calcium phosphate drug delivery ibuprofen nanostructure
Xin-Yu Zhao Ying-Jie Zhu Feng Chen Jin Wu
State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics,Chinese Academy of Sciences Shanghai,200050 (P.R.China)
国内会议
2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
上海
英文
1-7
2012-08-15（万方平台首次上网日期，不代表论文的发表时间）