Antitumor efficacy of electrospun hydroxyapatite nanoparticles/poly(lactic-co-glycolic acid) composite nanofibers encapsulated with doxorubicin
The utility of nanofibrous electrospun composite scaffolds has attracted much interest in servingas drug delivery vehicles in recent years. In this present study, we attempted to first encapsulate ananticancer drug, doxorubicin (DOX) using an inorganic rod-like nano-hydroxyapatite (n-HA). Then, theDOX-loaded n-HA particles were mixed with poly(lactic-co-glycolic acid) (PLGA) solution to fabricateelectrospun hybrid nanofibers. The formed drug-loaded composite nanofibers were characterized usingscanning electron microscopy, transmission electron microscopy, laser scanning confocal microscope andmechanical testing. In vitro DOX release behavior was examined using UV-Vis spectroscopy at neutral andacidic conditions, respectively. We show that DOX is able to be successfully loaded onto the surface of then-HA and the formed composite fibers have a uniform and continuous fibrous morphology. Importantly, theloaded DOX showed a sustained release profile as well as a significant improvement of mechanicaldurability. With the reduced burst-release profile, the organic/inorganic hybrid nanofibers may be able to beused as a drug delivery carrier for encapsulation and sustained release of different drugs for differentbiomedical applications.
Electrospinning Poly(lactic-co-glycolic acid) Nano-hydroxyapatite Doxorubicin Releaseproperty
Zheng Fuyin Wang Shige Shen Mingwu Shi Xiangyang
Key Laboratory of Textile Science & Technology,Ministry of Education College of Chemistry,Chemical E College of Material Science and Engineering Donghua University,Shanghai 201620 College of Chemistry,Chemical Engineering and Biotechnology
国内会议
2012上海市研究生学术论坛暨第三届上海交通大学医(理)工研究生学术论坛
上海
英文
1-9
2012-08-15（万方平台首次上网日期，不代表论文的发表时间）