Characterization of event-related potentials in obsessive compulsive disorder patients Comparison with depression and generalized anxiety disorder patients
BACKGROUND: Study results of event-related potential in obsessive compulsive disorder (OCD)remain controversial, potentially as a result of different instruments utilized and their differingtechnical characteristics.OBJECTIVE: To investigate the differences in several common event-related potentials, I.e.Contingent negative variations, P300, and mismatch negativity (MMN), in OCD patients, depressionpatients, generalized anxiety disorder (GAD) patients, and healthy controls.DESIGN, TIME AND SETTING: A case-control study was performed in the Department ofElectrophysiology, Shanghai Mental Health Center, from May 2002 to December 2005.PARTICIPANTS: A total of 38 OCD patients, 20 depression patients, and 18 GAD patients, whowere diagnosed according to the criteria of Chinese Classification of Mental Disorders (Version 3),formulated by the Chinese Psychiatry Association, were selected from the Outpatient Department ofShanghai Mental Health Center. Patients with two or more the above diseases were excluded. In .Addition, 28 healthy people, sex and age matched, were selected as controls.METHODS: Contingent negative variations, P300, and MMN were recorded by a Nicolet SpiritInstrument. All electrodes were attached at Cz according to the International 10-20 system, with themastoid leads as reference and Fpz as ground.MAIN OUTCOME MEASURES: Amplitude and latency of contingent negative variations, P300, andMMN.RESULTS: The contingent negative variations, P300, and MMN were different (P < 0.01). OCDpatients showed an increased Mi amplitude compared with controls, depression, and GAD patients(P < 0.01). Target P300 amplitudes were significantly lower in OCD, depression, and GAD patientscompared with controls (P < 0.01). Moreover, N2 latency and latencey of MMN were prolonged inOCD and depression groups compared with controls (P < 0.05).CONCLUSION: Event-related potentials were different in depression, GAD, and OCD patients andhealthy controls. In particular, OCD patients exhibited unique characteristics.
obsessive compulsive disorder depression generalized anxiety disorder contingent negative variation event-related potential-P300 mismatch negativity
YingzhiLu WenbinZong Hanzhen Dong FaxinWang Jinyu Pu Xingshi Chen Yunxiang Tang
Department of Psychiatry, Fifth People”s Hospital, Zibo 255120, Shandong Province, China Department of Neurophysiology, Shanghai Mental Health Center, Shanghai Jiao Tong University, Shangha
国内会议
中国第九届森田疗法学术大会暨天津市心理卫生协会2012学术年会
天津
英文
243-246
2012-08-24（万方平台首次上网日期，不代表论文的发表时间）