CD4+Foxp3+Regulatory T cell Impairment by Paclitaxel is Independent of Toll-1ike Receptor 4 but via regulation of Bcl-2/Bax

摘要：

1. IntroductionPaclitaxel (PTX) is considered to be one of the most potent antitumor agents for the treatment of various tumors”l”. Although the structure of PTX is quite different from LPS, it was found to trigger many LPS-like activities through TLR4 pathway ”2”. The mammalian TLRs family members are vital in the connection between innate and adaptive immune response. In the present study, we investigated the effect of PTX on CD4+Foxp3+ regulatory T (Treg) cells and CD4+Foxp3- effector T (Teff) cells, and the mechanism behind it, which may help clarify the role of PTX on immune system.

作者: 朱颖 储以微

作者单位: 复旦大学上海医学院06级临床医学(八年制) 复旦大学上海医学院免疫学系

会议类型: 国内会议

会议名称: 第四届全国大学生创新年会

会议地点: 上海

会议语种:英文

页码: 65-67

在线出版日期: 2011-10-22（万方平台首次上网日期，不代表论文的发表时间）