Interactive function between prefrontal cortex and striatum revealed by local field potential
The prefrontal cortex (PFC) and the striatum have mutual connections through direct and indirect pathways. Despite theirclose connections, it has been suggested that the PFC and the striatum may play different roles in behavioral control: the PFC mayselect actions required by external cognitive demands and the striatum may guide animal’s behaviors driven by internal motivation.But it is not clear that how the two structures cooperate and compete with each other to determine a motor output, in particular in thecase when their choices are inconsistent. To investigate this issue, we used multi-electrodes to record local field potentials (LFPs)simultaneously from the lateral PFC (LPFC) and the striatum when a monkey performed a sequential paired-association task withasymmetric reward schedule. Frequency power analysis of LFPs showed double dissociable functions between the LPFC and thestriatum. Coherence and Granger-causality analysis revealed that the strength of functional connectivity between the LPFC andstriatum was greater in small than in large reward trials, and greater in correct trials than in erroneous trials. Our results suggest theLPFC has strong interaction with the striatum, which may regulate monkey’s behavior correctly.
Prefrontal cortex Striatum Local field potential Reward Functional connectivity
Xiaochuan Pan Masamichi Sakagami
Institute for Cognitive Neurodynamics, East China University of Science and Technology, China Brain Brain Science Institute, Tamagawa University, Japan
国内会议
哈尔滨
英文
1-14
2011-08-22（万方平台首次上网日期，不代表论文的发表时间）