Rapid and simultaneous study on drug-protein binding of four furocoumarins by hollow fiber liquid phase microextraction

摘要：

Hollow fiber liquid phase microextraction (HF-LPME) coupled with high performance chromatography (HPLC) was applied to research the binding of four furocoumarins (psoralen, oxypeucedanin, imperatorin and isoimperatorin) to bovine serum albumin. The results suggest that the percent of four furocoumarins-protein binding should not rely on the concentrations of furocoumarins and protein, and four target drugs scarcely compete for binding bites of protein. Hence, furocoumarin-protein binding percents can be determined simultaneously and rapidly by the approach.

关键词： Hollow fiber liquid phase microextraction Drug-protein binding Simultaneous determination Furocoumarins

作者: Shuang Hu Yan Jie Zhang Xiao Hong Bai

作者单位: School of Pharmacy, Shanxi Medical University, Taiyuan 030001, PR China

会议类型: 国内会议

会议名称: 第十六届有机分析与生物分析学术研讨会

会议地点: 呼和浩特

会议语种:英文

页码: 50-50

在线出版日期: 2011-07-20（万方平台首次上网日期，不代表论文的发表时间）