Insight into IgG Fc N-glycosylation profiling with age, sex and correlation-associated analyses based on MALDI-FTICR MS data

摘要：

Relative abundance of serum IgG Fc N-glycosylation was profiled by FTICR-MS with intermediate-pressure MALDI source, following micro-scale solid phase extraction (μSPE) enrichment for IgG glycopeptides. A total of 15 glycoforms were obtained from control individuals. The glycoform incidences were subjected to statistical analyses. Age- and sex-related alteration in IgG glycoform incidences was found as an inherent property of IgG Fc N-glycosylation. Besides, there were extensive correlations among IgG glycoforms.

关键词： IgG glycosylation MALDI-FTICR MS thyroid cancer

作者: Guoqiang Chen Yumei Guo Xiaodong Wang Hui Liu Gaoguang Song Shuai Guo Fenjie Li Zhili Li

作者单位: Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academ

会议类型: 国内会议

会议名称: 第十六届有机分析与生物分析学术研讨会

会议地点: 呼和浩特

会议语种:英文

页码: 72-72

在线出版日期: 2011-07-20（万方平台首次上网日期，不代表论文的发表时间）