Evaluation of the association between the exon 6 of PPAR-γ polymorphism and polycystic ovary syndrome among Han Chinese women
Objective：To evaluate the association between the exon 6 polymorphism of Human peroxisome proliferators activator receptors gamma(PPAR-7)gene and polycystic ovary syndrome(PCOS)among Han Chinese women． Methods：To collect the clinical characteristics and the blood samples of 111 patients with PCOS and 92 healthy controls．The exon 6 polymorphism of PPAR-γ gene was genotyped by PCR-RFLP． Results：The CT／TT genotype frequency in PCOS group Was significantly higher than that in control group (P<0．01)．The frequency of T allele in PCOS group was obviously higher than that in control group(P<0．0 1)．The BMI(27．95+4．62 vs 25．75±4．50 P=0．016)，waistline(91．00±11．12 vs 83．39±12．89 P=0．002)，hipline (103．59±8．95 vs 98．10±11．21 P=0．01)and FPG(5．24±1．55 vs 4．63±0．59 P=0．02)of PCOS patients in CT／TT genotypes were higher than that in CC genotype． Conclusions：The T allele may be associated with the obesity and the higher level of FPG in patients with PCOS．The exon 6 polymorphism of PPAR-γ gene may have the risk susceptibility of Han Chinese women．
polycystic ovary syndrome(PCOS) peroxisome proliferators-activated receptor-γ (PPAR-T) polymorphism genetic association
Cui-fang Hao Ning Zhang Li Ge Zhi-yan Xu Xiong Wang
Reproductive Medical Center,Yantai Yuhuangding Hospital,the Affiliated Yantai Yuhuangding Hospital o Reproductive Medical Center,Weihai Maternal and Child Hospital,Weihai,P.R.China
国内会议
烟台
英文
118-127
2012-07-27（万方平台首次上网日期，不代表论文的发表时间）