Metabolite target analysis of symptomatic gout based on human urine combined with pattern recognition technique
It is commonly acknowledged that the development of gout is a multi-step process, from asymptomatic hyperuricemia, to acute gouty arthritis and intercritical gout, finally to chronic tophaceous gout ”1-3”. The preliminary consequence in the development of gout is hyperuricemia. However, hyperuricemia is not necessarily related to gout and as many as 42％ of acute gout patients might have normal levels of serum uric acid ”4, 5”. Therefore, serum uric acid alone as evaluated indicator for clinical diagnosis is insufficient. Identification of novel biomarkers for gout diagnosis is highly desirable to prevent the destruction of joints caused by tophaceous gout. Metabolite target analysis was established for urine based on fifteen endogenous metabolisms by high performance liquid chromatography-diode array detector (HPLC-DAD). Pattern recognition techniques were performed in order to discover significant metabolites from 15 metabolites.
gout chemometrics metabolomics
YunLiu Xiao-Ming Sun Duo-Long Di
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine
国内会议
兰州
英文
9-10
2012-07-01（万方平台首次上网日期，不代表论文的发表时间）