Relationships between interleukin-12B and interleukin-10 gene polymorphisms and hepatitis C in Chinese Han hemodialysis patients
Background and Aims Hepatitis C virus (HCV) commonly causes a chronic infection but portion of hemodialysis patients are able to resistant to HCV infection even clear the virus naturally. Interleukin-10 (IL-10) and interleukin-12 (IL-12) are crucial regulators of the immune response to T-helper 1 (Thl) or T-helper 2 (Th2) categories and play a role in autoimmune and infectious diseases. This study was undertaken to investigate the possible association of genetic polymorphisms of 3” untranslated region (3”UTR) of the IL-12B (-1188) and IL-10 (-592 and -819) andhepatitis C in Chinese Han hemodialysis (HD) patients. Methods The genotyping of IL-12B 3”UTR and IL-10 -592 and -819 were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Results Compared with the IL-12B-AA genotype, CC and combined CC/AC genotypes were associated with a significant decreased risk of HCV infection in Chinese hemodialysis patients (P <0.001). However, the IL-10-592 and -819 genotypes were not found significant difference both between the anti-HCV (+) and anti-HCV (-) patients (P>0.05) and the persistent infection and viral clearance HD patients (P>0.05). Conclusions The present study indicated that the polymorphisms of IL-12B 3”UTR might contribute to the susceptibility of HCV infection in Chinese HD population.
Interleukin-12B gene IL-10 gene Polymorphisms Hepatitis C Hemodialysis
Bei Zhu Cuiyu Wang Xiaoli Zhang Juan He Jianqing Wu Rongbin Yu Weihong Zhao
Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jian Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, N
国内会议
北京
英文
213-220
2012-05-11（万方平台首次上网日期，不代表论文的发表时间）