Enzymic effects of lidocaine on myocardial ischemia-reperfusion injury in isolated rat hearts
Lidocaine is a commonly used local anesthetics clinically, affectting Purkinje fibers and ventricular myocytes, inhibitting sodium influx, and promoting outflow of potassium, that can also be used to treat perioperative ventricular disorders especially fast ventricular premature. Researches showed that lidocaine at low concentration could prevent myocardial cells from ischemia reperfusion injury”1,2”, even with preconditioning”3,4”. However, the mechanism that acts myocardial cells remains unclear. In this study, we observed isolated rat”s heart perfused with KHB containing different concentration of lidocaine in order to found a reasonable concentration of it on myocardial protection, to explore its possible mechanism, and referred a reference for clinical myocardial protection.
Fang Wenqian Lü Guoyi Deng Naifeng
The Second Hospital of Tianjin Medical University
国内会议
天津
英文
188-191
2009-12-05（万方平台首次上网日期，不代表论文的发表时间）