Sevoflurane postconditioning attenuates hypoxia/reoxygenation injury on neonatal rat” s cardiomyocytes in vitro: the role of p38 mitogen-activated protein kinases pathway

摘要：

It has been reported that sevoflurane postconditioning can protect cardiomyocytes against hypoxia/reperfusion injury”1”. However, the mechanisms remains incompletely studied. Some researches reported that sevoflurane postconditioning had been mediated, at least in part, by the members of mitogen-activated protein kinases (MAPK) such as phosphatidylinositol-3-kinase (PI3K) and extracellular signal-regulated kinases 1/2 (ERK1/2) activation”2,3”. P38 MAPK is the third member of MAPK family. Whether p38 MAPK mediate the cardioprotective effect is still unclear. In this study we aimed to investigate the role of p38 MAPK pathway on sevoflurane postconditioning against hypoxia/reoxygenation injury in primarily cultured neonatal rat”s cardiomyocytes in vitro.

作者: ZHUANG Xin-Qi LV Guo- Yi

作者单位: Department of Anesthesiology, 2nd Hospital of Tianjin Medical University

会议类型: 国内会议

会议名称: 天津医学会麻醉学分会2009年度学术年会

会议地点: 天津

会议语种:英文

页码: 192-196

在线出版日期: 2009-12-05（万方平台首次上网日期，不代表论文的发表时间）